Study: Overactive bladder medication linked to depression in women

Women treated with antimuscarinics for overactive bladder syndrome are more likely to be diagnosed with depression after treatment onset than overactive bladder patients not treated with the medications, according to a new study published in The Journal of Clinical Pharmacology.

For the retrospective study, researchers in Taiwan examined health data compiled in the nation's health insurance database on 1,952 overactive bladder patients diagnosed between 2001 and 2010 and treated with antimuscarinics, which can significantly depress bladder contractions and improve symptoms. Researchers then compared this data with health information on 9,760 overactive bladder patients not treated with antimuscarinics. Patients who took the prescribed medications were 38 percent more likely to be diagnosed with depression within three years of starting treatment than patients not treated with the medications.

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"We recommend that clinicians be alert to the relationship between antimuscarinics and depressive disorder in OAB (overactive bladder) women," concluded the study's authors. "In addition, clinicians can provide appropriate instructions for OAB women who receive antimuscarinics to seek health and medical services as soon as possible if they have relevant clinical symptoms of depressive disorder."

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